Soluble corn fiber increases bone calcium retention in postmenopausal women in a dose-dependent manner: a randomized crossover trial.

Dietary soluble corn fiber (SCF) significantly improves calcium absorption in adolescents and the bone strength and architecture in rodent models.
In this study, we aimed to determine the skeletal benefits of SCF in postmenopausal women.
We used our novel technology of determining bone calcium retention by following the urinary appearance of (41)Ca, a rare long-lived radioisotope, from prelabeled bone to rapidly and sensitively evaluate the effectiveness of SCF in reducing bone loss. A randomized-order, crossover, double-blinded trial was performed in 14 healthy postmenopausal women to compare doses of 0, 10, and 20 g fiber from SCF/d for 50 d.
A dose-response effect was shown with 10 and 20 g fiber from SCF/d, whereby bone calcium retention was improved by 4.8% (P < 0.05) and 7% (P < 0.04), respectively. The bone turnover biomarkers N-terminal telopeptide and osteocalcin were not changed by the interventions; however, a significant increase in bone-specific alkaline phosphatase, which is a bone-formation marker, was detected between 0 and 20 g fiber from SCF/d (8%; P = 0.035). CONCLUSION:
Daily SCF consumption significantly increased bone calcium retention in postmenopausal women, which improved the bone calcium balance by an estimated 50 mg/d.





結果:用量応答効果は、SCF由来繊維の一日当たり摂取量10gおよび20gで示され、骨カルシウム保持は、それぞれ4.8%(P <0.05)および7%(P <0.04)改善された。 骨代謝回転マーカーであるN末端テロペプチドとオステオカルシンは介入によって変化しなかった。 しかしSCF由来繊維の一日当たり摂取量0〜20gの間で、骨形成マーカーである骨特異的アルカリホスファターゼの有意な増加(8%; P=0.035)が検出された。