Aloe vera in the treatment for oral submucous fibrosis - a preliminary study.

Oral submucous fibrosis (OSMF) is a potentially malignant disorder of the oral mucosa, mainly associated with the practice of chewing gutka and betel quid. The pathogenesis is obscure, and till date, no definitive therapy is available for the management of OSMF. Hence, this preliminary study was carried out to compare the efficacy of Aloe vera with antioxidants in the treatment for OSMF.

Twenty study subjects with OSMF were included in the study. Patients were divided into two groups. There were 10 patients in each group; group A subjects received 5 mg of aloe vera gel to be applied topically three times daily for 3 months and group B subjects received antioxidant capsules twice daily for 3 months. The results were analyzed with paired 't' test and unpaired 't' test.

Aloe vera responded better in all the parameters assessed and responded in all the clinicohistopathological stages particularly in those with mild-stage clinically and early-stage histopathologically. Aloe vera showed a statistically significant reduction in burning sensation (P = 0.008), improvement in mouth opening (P = 0.02), and cheek flexibility (P = 0.01) on comparing with the antioxidant group.

INTERPRETATION AND CONCLUSION: Overall assessment of the parameters depicted that Aloe vera group showed a better treatment response compared to the antioxidants group. It reduces the burning sensation and improves mouth opening thereby enhanced the patients' compliance. It proves to be a relatively safe, can be applied topically, easily available, economical, noninvasive, and efficacious in the treatment for OSMF.

「口腔粘膜下線維症治療におけるアロエベラ - 予備研究」



アロエベラは評価した全パラメータでより反応が優れ、全ての臨床病理組織学的ステージ、特に臨床的に軽度のステージと、病理組織学的に初期ステージにおいて反応した。アロエベラは、灼熱感(P =0.008)、開口の改善(P=0.02)、及び頬の柔軟性(P=0.01)において、酸化防止剤群と比べて統計的に有意な低下を示した。